Medial entorhinal cortex mediates learning of context-dependent interval timing behavior

Bigus, E. R.*, Lee, H. W.*, Bowler, J. C., Shi, J., & Heys, J. G. (2024). Nature Neuroscience, 1-12. https://doi.org/10.1038/s41593-024-01683-7

*indicates co-lead authorship

Inactivation of the medial entorhinal cortex selectively disrupts learning of interval timing

Heys JG, Wu Z, Allegra Mascaro AL, Dombeck DA (2020). Cell Reports. 32(12):108163.

Navigating through time: A spatial navigation perspective on how the brain may encode time

Issa JB, Tocker G, Hasselmo ME, Heys JG, Dombeck DA (2020). Annual Review of Neuroscience. 43:73-93.

Evidence for a subcircuit in medial entorhinal cortex representing elapsed time during immobility

Heys JG, Dombeck DA (2018). Nature Neuroscience, 21(11), 1574-1582.

Physiological properties of neurons in bat entorhinal cortex exhibit an inverse gradient along the dorsal-ventral axis compared to entorhinal neurons in rat

Heys JG, Shay CF, MacLeod KM, Witter MP, Moss CF, Hasselmo ME (2016). Journal of Neuroscience, 36(16), 4591-9.

The functional micro-organization of grid cells revealed by cellular-resolution imaging

Heys JG, Rangarajan KV, Dombeck DA (2014). Neuron, 84(5), 1079-90.

3D mapping in the brain

Discussed in perspective Barry C, Doeller CF (2013). Science, 340(6130):279-80. doi: 10.1126/science.1237569. PMID: 23599468.

Bat and rat neurons differ in theta-frequency resonance despite similar coding of space

Heys JG, MacLeod KM, Moss CF, Hasselmo ME (2013). Science, 340(6130), 363-7.

Possible role of acetylcholine in regulating spatial novelty effects on theta rhythm and grid cells

Barry C, Heys JG, Hasselmo ME (2012). Frontiers in Neural Circuits, 6, 5.

Neuromodulation of I(h) in layer II medial entorhinal cortex stellate cells: a voltage-clamp study

Heys JG, Hasselmo ME (2012). Journal of Neuroscience, 32(26), 9066-72.

Effects of acetylcholine on neuronal properties in entorhinal cortex

Heys JG, Schultheiss NW, Shay CF, Tsuno Y, Hasselmo ME (2012). Frontiers in Behavioral Neuroscience, 6, 32.

Cholinergic modulation of the resonance properties of stellate cells in layer II of medial entorhinal cortex

Heys JG, Giocomo LM, Hasselmo ME (2010). Journal of Neurophysiology, 104(1), 258-70.

A phase code for memory could arise from circuit mechanisms in entorhinal cortex

Hasselmo ME, Brandon MP, Yoshida M, Giocomo LM, Heys JG, Fransen E, Newman EL, Zilli EA (2009). Neural Networks, 22(8), 1129-38.